The most difficult hole on the course for a reason.
There are Out of Bounds down the entire length of the hole, and drifting into the trees on either side of the fairway will certainly add at least one shot to your score.
Trees in the fairway pose problems with your second and perhaps third shots.
The ideal Tee Shot would be slightly to the left or right of the first large tree in the fairway. But this is only for the very longest of hitters. Most will be well short of this so your next shot is best to be right of the next two trees on the left side of fairway.